Andrew Arnold, M.D.
 Center Director
Murray-Heilig Chair in Molecular Medicine
Professor of Medicine and Genetics and Developmental Biology
Chief, Division of Endocrinology
Email:
molecularmedicine@uchc.edu
Phone: 860-679-7640
Fax: 860-679-7639
Research Interests
The most longstanding interest of our laboratory has been
in the molecular genetic underpinnings of tumors of the
endocrine glands. It was in the context of a search for a
parathyroid tumor oncogene lying adjacent to a clonal
chromosomal breakpoint that we discovered cyclin D1 (PRAD1).
Cyclin D1 has proven to play a key role in cell cycle
regulation, and has emerged as a major human oncogene,
important in multiple types of tumors including breast
cancer and B-cell lymphoma. We are currently pursuing a
number of approaches, including the use of transgenic mouse
models, to learn more about the precise mechanisms by which
cyclin D1 exerts its oncogenic effects. In addition to the
cyclin D1 work, we are continuing a major initiative seeking
additional genes that contribute to endocrine neoplasia. In
this context, we identified the HRPT2 gene as a major factor
in the development of malignant parathyroid tumors, a
finding that carries important clinical implications.
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